As an uncontrolled inflammatory response to infection, sepsis and sepsis induced organ
dysfunction are great threats to the lives of septic patients. Unfortunately, the pathogenesis
of sepsis is complex and multifactorial, which still needs to be elucidated. Pyroptosis is a
newly discovered atypical form of inflammatory programmed cell death, which depends on
the Caspase-1 dependent classical pathway or the non-classical Caspase-11 (mouse) or
Caspase-4/5 (human) dependent pathway. Many studies have shown that pyroptosis is …