Pyrrolidine dithiocarbamate (PDTC)/Cu complex induces lung epithelial cell apoptosis through mitochondria and ER-stress pathways
YW Chen, KL Chen, CH Chen, HC Wu, CC Su, CC Wu… - Toxicology Letters, 2010 - Elsevier
Pyrrolidine dithiocarbamate (PDTC) is widely used in pesticides, fungicides, insecticides,
and herbicides. Copper (Cu) is a toxic heavy metal in the environment, and an essential
trace metal element in the body, which is involved in many biological processes as a
catalytic cofactor. The present study is designed to investigate the cellular toxicity of PDTC,
CuCl2, and PDTC/Cu complex exposure in lung alveolar epithelial cells that serve primary
structural and functional roles in the lungs. The results showed that PDTC or CuCl2 alone …
and herbicides. Copper (Cu) is a toxic heavy metal in the environment, and an essential
trace metal element in the body, which is involved in many biological processes as a
catalytic cofactor. The present study is designed to investigate the cellular toxicity of PDTC,
CuCl2, and PDTC/Cu complex exposure in lung alveolar epithelial cells that serve primary
structural and functional roles in the lungs. The results showed that PDTC or CuCl2 alone …
Pyrrolidine dithiocarbamate (PDTC)/Cu complex induces lung epithelial cell apoptosis through mitochondria and ER-stress pathways.
CYW Chen YaWen, CKL Chen KuoLiang… - 2010 - cabidigitallibrary.org
Pyrrolidine dithiocarbamate (PDTC) is widely used in pesticides, fungicides, insecticides,
and herbicides. Copper (Cu) is a toxic heavy metal in the environment, and an essential
trace metal element in the body, which is involved in many biological processes as a
catalytic cofactor. The present study is designed to investigate the cellular toxicity of PDTC,
CuCl2, and PDTC/Cu complex exposure in lung alveolar epithelial cells that serve primary
structural and functional roles in the lungs. The results showed that PDTC or CuCl2 alone …
and herbicides. Copper (Cu) is a toxic heavy metal in the environment, and an essential
trace metal element in the body, which is involved in many biological processes as a
catalytic cofactor. The present study is designed to investigate the cellular toxicity of PDTC,
CuCl2, and PDTC/Cu complex exposure in lung alveolar epithelial cells that serve primary
structural and functional roles in the lungs. The results showed that PDTC or CuCl2 alone …
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