Health-related quality of life (HRQoL) is defined as “the perception and evaluation by
patients themselves of the impact caused on their lives by the disease and its
consequences.” HRQoL is conceptualized as a combination of physical, psychological, and
social well-being in the context of a particular disease. Following earlier studies revolving on
the impact of the classic motor symptoms of Parkinson's disease on HRQoL, mounting
evidence have been produced that nonmotor symptoms (NMS) significantly and …

Background The role of subthreshold depression (subD) in Parkinson's Disease (PD) is not
clear. The present study aimed to compare the quality of life (QoL) in PD patients with subD
vs patients with no depressive disorder (nonD). Factors related to subD were identified.
Material and methods PD patients and controls recruited from the COPPADIS cohort were
included. SubD was defined as Judd criteria. The 39-item Parkinson's disease
Questionnaire (PDQ-39) and the EUROHIS-QOL 8-item index (EUROHIS-QOL8) were used …