Quantification of cocaine and cocaine metabolites in dried blood spots from a controlled administration study using liquid chromatography–tandem mass spectrometry
Cocaine is a common illicit stimulant and is mainly metabolized by hydrolysis to
benzoylecgonine (BE) and ecgonine methyl ester (EME), but also to minor metabolites like
norcocaine, or hydroxy‐BE. When ethanol is present, cocaethylene is formed. Dried blood
spot (DBS) sampling is a minimally invasive microsampling technique with possible
advantages for analyte stability and ease of storage, making it an attractive matrix in forensic
and clinical settings. We developed a liquid chromatography–tandem mass spectrometry …
benzoylecgonine (BE) and ecgonine methyl ester (EME), but also to minor metabolites like
norcocaine, or hydroxy‐BE. When ethanol is present, cocaethylene is formed. Dried blood
spot (DBS) sampling is a minimally invasive microsampling technique with possible
advantages for analyte stability and ease of storage, making it an attractive matrix in forensic
and clinical settings. We developed a liquid chromatography–tandem mass spectrometry …
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