Quantitative measurement of histamine H1 receptors in human brains by PET and [11C] doxepin

H Mochizuki, Y Kimura, K Ishii, K Oda, T Sasaki… - Nuclear medicine and …, 2004 - Elsevier
The aim of this study is to establish a method for quantitative measurement of histamine H1
receptor (H1R) in human brain by PET and [11C] doxepin ([11C] DOX). The estimated
parameters with a two-compartment model were stable for the initial values for parameter
estimation but those with a three-compartment model were not. This finding suggests that
the H1R measured by the [11C] DOX and PET can be evaluated with a two-compartment
model.
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