[HTML][HTML] Quantitative prediction of human drug pharmacokinetic responses using multiple vascularized organ chips coupled by fluid transfer
Nature biomedical engineering, 2020•ncbi.nlm.nih.gov
Pharmacokinetic and pharmacodynamic (PK/PD) analysis required to advance drug
compounds towards clinical testing is commonly carried out in animals, however, the results
are often not predictive of human outcomes1. In vitro PK/PD modeling approaches exist2, 3,
but they fail to provide quantitative in vitro-to-in vivo translation (IVIVT) of human PK
compounds towards clinical testing is commonly carried out in animals, however, the results
are often not predictive of human outcomes1. In vitro PK/PD modeling approaches exist2, 3,
but they fail to provide quantitative in vitro-to-in vivo translation (IVIVT) of human PK
Pharmacokinetic and pharmacodynamic (PK/PD) analysis required to advance drug compounds towards clinical testing is commonly carried out in animals, however, the results are often not predictive of human outcomes1. In vitro PK/PD modeling approaches exist2, 3, but they fail to provide quantitative in vitro-to-in vivo translation (IVIVT) of human PK
ncbi.nlm.nih.gov
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