Quantitative translation of dog-to-human aging by conserved remodeling of the DNA methylome
All mammals progress through similar physiological stages throughout life, from early
development to puberty, aging, and death. Yet, the extent to which this conserved
physiology reflects underlying genomic events is unclear. Here, we map the common
methylation changes experienced by mammalian genomes as they age, focusing on
comparison of humans with dogs, an emerging model of aging. Using oligo-capture
sequencing, we characterize methylomes of 104 Labrador retrievers spanning a 16-year …
development to puberty, aging, and death. Yet, the extent to which this conserved
physiology reflects underlying genomic events is unclear. Here, we map the common
methylation changes experienced by mammalian genomes as they age, focusing on
comparison of humans with dogs, an emerging model of aging. Using oligo-capture
sequencing, we characterize methylomes of 104 Labrador retrievers spanning a 16-year …
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