Quercetin protects liver injury induced by bile duct ligation via attenuation of Rac1 and NADPH oxidase1 expression in rats
R Kabirifar, F Safari, A Karimollah, A Moradi… - … & Pancreatic Diseases …, 2017 - Elsevier
Background Bile duct ligation (BDL) and subsequent cholestasis are correlated with
oxidative stress, hepatocellular injury and fibrosis. Quercetin is a flavonoid with antifibrotic,
and hepatoprotective properties. However, the molecular mechanism underlying quercetin-
mediated hepatoprotection is not fully understood. The current study was to evaluate
mechanisms of hepatoprotective effect of quercetin in BDL rat model. Methods We divided
male Wistar rats into 4 groups (n= 8 for each): sham, sham+ quercetin (30 mg/kg per day) …
oxidative stress, hepatocellular injury and fibrosis. Quercetin is a flavonoid with antifibrotic,
and hepatoprotective properties. However, the molecular mechanism underlying quercetin-
mediated hepatoprotection is not fully understood. The current study was to evaluate
mechanisms of hepatoprotective effect of quercetin in BDL rat model. Methods We divided
male Wistar rats into 4 groups (n= 8 for each): sham, sham+ quercetin (30 mg/kg per day) …