Quinones as antimycobacterial agents

T Tran, E Saheba, AV Arcerio, V Chavez, Q Li… - Bioorganic & medicinal …, 2004 - Elsevier
… Alkylation is when quinones are activated inside cells and become covalently attached …
quinones against the notable prokaryotic genus Mycobacterium. Determination of native quinone

The synthesis and evaluation of quinolinequinones as anti-mycobacterial agents

KT Santoso, A Menorca, CY Cheung, GM Cook… - Bioorganic & medicinal …, 2019 - Elsevier
… the quinone ring to be essential for anti-tubercular activity. Indeed, the pharmaceutical
properties of quinones is … active quinones correlated with good therapeutic activity.15, 16, 17, 18 …

Antitubercular and antibacterial activity of quinonoid natural products against multi‐drug resistant clinical isolates

D Dey, R Ray, B Hazra - Phytotherapy research, 2014 - Wiley Online Library
… All the tested quinones exhibited antimycobacterial and broad spectrum antibacterial activity,
particularly against M. tuberculosis (lowest MIC 0.25 µg/mL) and Gram-positive bacteria (…

Discovery of selective menaquinone biosynthesis inhibitors against Mycobacterium tuberculosis

J Debnath, S Siricilla, B Wan, DC Crick… - Journal of medicinal …, 2012 - ACS Publications
… development of selective antimycobacterial agents with strong … We have identified
selective antimycobacterial MenA … identify novel chiral antimycobacterial MenA inhibitors with …

QcrB in Mycobacterium tuberculosis: The new drug target of antitubercular agents

A Bahuguna, S Rawat, DS Rawat - Medicinal Research …, 2021 - Wiley Online Library
… ETC has two types of electron carriers for the transport of electrons: quinones and cytochromes.
… The campaign resulted in the discovery of two new classes of antimycobacterial agents

Marine natural products as antituberculosis agents

KA El Sayed, P Bartyzel, X Shen, TL Perry, JK Zjawiony… - Tetrahedron, 2000 - Elsevier
agents. New additions to the established antituberculosis structural classes quinone-…
In this paper we report three new antimycobacterial structural classes; C-19 hydroxy steroids…

Anti-infective quinone derivatives of recent patents

J Koyama - Recent Patents on Anti-Infective Drug Discovery, 2006 - benthamdirect.com
… Two types of chemotherapeutic agents are synthetic drugs and antibiotics. In this section,
5 patents are classified into 1) antimycobacterial, 2) antichlamydial and/or anti-methicillin-…

Effect of an Oxadiazoline and a Lignan on Mycolic Acid Biosynthesis and Ultrastructural Changes of Mycobacterium tuberculosis

E Baquero, W Quinones, W Ribon… - Tuberculosis …, 2011 - Wiley Online Library
… In this paper, we report the antimycobacterial activity of three lignans and two oxadiazoline
derivatives against M. tuberculosis H37Rv analyzed by mass spectrometry and transmission …

1,4-Benzoquinone antimicrobial agents against Staphylococcus aureus and Mycobacterium tuberculosis derived from scorpion venom

EN Carcamo-Noriega… - Proceedings of the …, 2019 - National Acad Sciences
… be also the mechanism of the antimycobacterial activity. Several bactericidal … quinones
doxorubicin, daunorubicin, and mitomycin C, which are clinically used chemotherapeutic agents

Antimycobacterial natural products

BR Copp - Natural Product Reports, 2003 - pubs.rsc.org
… have been evaluated as potential antimycobacterial agents. Cerulenin, structurally identified
… acetogenic quinones 6-Paradol (51) and 6-shogaol (52) were isolated as antimycobacterial