Aims Xp11 rearrangement in renal cell carcinoma (RCC) typically involves gene fusion to
the gene encoding transcription factor E3 (TFE3), a member of the microphthalmia‐
associated transcription factor family on chromosome Xp11. 2. Dual‐colour break‐apart
fluorescence in‐situ hybridisation (FISH) is recommended to confirm histological diagnoses.
Recently, RNA‐binding motif protein 10 (RBM10), encoded by a gene on chromosome
Xp11. 3, was identified as a chimeric partner of TFE3; thus, RBM10–TFE3 fusion results from …

… Recently, RNA binding motif protein 10 (RBM10), on chromosome Xp11.3, was identified
as a chimeric partner of TFE3; thus, RBM10-TFE3 fusion results from paracentric inversion.
It is known that RBM10-TFE3 RCC may have false-negative results for TFE3 FISH. Methods:
We investigated the clinicopathological features of 10 patients with RBM10-TFE3 RCC.
Histological analysis, immunostaining, dualcolour break-apart FISH for …