RIAM activates integrins by linking talin to ras GTPase membrane-targeting sequences
HS Lee, CJ Lim, W Puzon-McLaughlin… - Journal of Biological …, 2009 - ASBMB
Rap1 small GTPases interact with Rap1-GTP-interacting adaptor molecule (RIAM), a
member of the MRL (Mig-10/RIAM/Lamellipodin) protein family, to promote talin-dependent
integrin activation. Here, we show that MRL proteins function as scaffolds that connect the
membrane targeting sequences in Ras GTPases to talin, thereby recruiting talin to the
plasma membrane and activating integrins. The MRL proteins bound directly to talin via
short, N-terminal sequences predicted to form amphipathic helices. RIAM-induced integrin …
member of the MRL (Mig-10/RIAM/Lamellipodin) protein family, to promote talin-dependent
integrin activation. Here, we show that MRL proteins function as scaffolds that connect the
membrane targeting sequences in Ras GTPases to talin, thereby recruiting talin to the
plasma membrane and activating integrins. The MRL proteins bound directly to talin via
short, N-terminal sequences predicted to form amphipathic helices. RIAM-induced integrin …
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