[PDF][PDF] RIFM fragrance ingredient safety assessment, pt-butyl-α-methylhydrocinnamic aldehyde, CAS Registry Number 80-54-6

AM Api, D Belsito, S Biserta… - Food and …, 2020 - fragrancematerialsafetyresource …
AM Api, D Belsito, S Biserta, D Botelho, M Bruze, GA Burton, J Buschmann, MA Cancellieri…
Food and Chemical Toxicology, 2020fragrancematerialsafetyresource …
The existing information supports the use of this material as described in this safety
assessment. pt-Butyl-α-methylhydrocinnamic aldehyde was evaluated for genotoxicity,
repeated dose toxicity, developmental and reproductive toxicity, local respiratory toxicity,
phototoxicity/photoallergenicity, skin sensitization, and environmental safety. D-ata show
that pt-butyl-α-methylhydrocinnamic aldehyde is not genotoxic. Data on pt-butyl-α-
methylhydrocinnamic aldehyde provide a calculated MOE of> 100 for the repeated dose …
Summary
The existing information supports the use of this material as described in this safety assessment. pt-Butyl-α-methylhydrocinnamic aldehyde was evaluated for genotoxicity, repeated dose toxicity, developmental and reproductive toxicity, local respiratory toxicity, phototoxicity/photoallergenicity, skin sensitization, and environmental safety. D-ata show that pt-butyl-α-methylhydrocinnamic aldehyde is not genotoxic. Data on pt-butyl-α-methylhydrocinnamic aldehyde provide a calculated MOE of> 100 for the repeated dose toxicity and developmental and reproductive toxicity endpoints. Data provided pt-butyl-α-methylhydrocinnamic aldehyde a NESIL of 4100 μg/cm2 for the skin sensitization endpoint. The phototoxicity/photoallergenicity endpoints were evaluated based on data and UV spectra; pt-butyl-α-methylhydrocinnamic aldehyde is not expected to be phototoxic/photoallergenic. The local respiratory toxicity endpoint was evaluated using the TTC for a Cramer Class I material, and the exposure to pt-butyl-α-methylhydrocinnamic aldehyde is below the TTC (1.-4 mg/day). The environmental endpoints were evaluated; pt-butyl-α-methylhydrocinnamic aldehyde was found not to be PBT as per the IFRA Environmental Standards, and its risk quotients, based on its current volume of use in Europe and North America (ie, PEC/PNEC), are< 1.
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