RNA encapsidation by SV40-derived nanoparticles follows a rapid two-state mechanism
Remarkably, uniform virus-like particles self-assemble in a process that appears to follow a
rapid kinetic mechanism. The mechanisms by which spherical viruses assemble from
hundreds of capsid proteins around nucleic acid, however, are yet unresolved. Using time-
resolved small-angle X-ray scattering (TR-SAXS), we have been able to directly visualize
SV40 VP1 pentamers encapsidating short RNA molecules (500mers). This assembly
process yields T= 1 icosahedral particles comprised of 12 pentamers and one RNA …
rapid kinetic mechanism. The mechanisms by which spherical viruses assemble from
hundreds of capsid proteins around nucleic acid, however, are yet unresolved. Using time-
resolved small-angle X-ray scattering (TR-SAXS), we have been able to directly visualize
SV40 VP1 pentamers encapsidating short RNA molecules (500mers). This assembly
process yields T= 1 icosahedral particles comprised of 12 pentamers and one RNA …
[引用][C] RNA Encapsidation by SV40-Derived Nanoparticles Follows a Rapid Two-State Mechanism
K Stanislav, A Roi, L Chenglei, G Avi, H Daniel… - 2012
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