Besides several causes, the researchers believed that erosion is a vital reason of land degradation. Therefore, understanding the nature and type of land erosion processes will benefit many sectors of society in a concerned region. The current study estimated the mean annual loss of soil in Al-Khabur River Basin (KhRB) in the northwest side of the western Zagros Range (Kurdistan Region/ Iraq). KhRB is a main tributary of the Tigris River. We have used DEM-SRTM, TRMM, the HWSD, and Landsat imagery having 30 m pixel resolution to apply the RUSLE model. We have calculated six factors, which are the factor of rainfall and runoff erosivity (R), the factor of soil erodibility (K), the factor of slope length (L), the factor of slope-steepness (S), the factor of cover and management (C), and the factor of support practice related to slope direction (P). Results of RUSLE show that the minimum and the maximum values of the annual soil losses were zero t⁻¹. ha⁻¹. y⁻¹and ~ 3618 t⁻¹. ha⁻¹. y⁻¹, respectively. The sum of the annual soil losses for the KhRB was 317,273,283.4 t⁻¹. ha⁻¹. y⁻¹with an average ~75.79 t⁻¹. ha⁻¹. y⁻¹. The southern and northeastern parts of the KhRB exhibit low and very low annual loss of soil (<10 t⁻¹. ha⁻¹. y⁻¹), while the central and northern parts of the KhRB exhibit high and very high annual loss of soil (>10 t⁻¹. ha⁻¹. y⁻¹). Around 19% of the KhRB holds very high value of the annual soil losses (>50 t⁻¹. ha⁻¹. y⁻¹). The study has found that the main factors that dominate the annual soil losses in the KhRB are LS, derived from the slope gradient and flow accumulation, and R factor, which is related to the precipitation. The most vulnerable areas to soil erosion are rough terrain, steep inclines, heavy precipitation, and low plant cover. Implementing the RUSLE model and anticipating soil loss distribution in the KhRB will help in potential land use and watershed management in Iraq.