Rabies means “to be mad”. Itsa zoonotic disease which is spread by animals mostly carnivores. Rabies considers as tropic disease. Its vaccine was invented in 1885 by Louis Pasteur and Emile Roux. About 60,000 people die globally per-year due to rabies. 1943, 1945, 1947, 1948, 1994 and 2014 are famous years of outbreaks of this disease. Between 2013 to 2016 in Latin America and the Caribbean many people outbreak of rabies. 36000, 22000, 1900 and 250 deaths occur in Asia, Africa, Central Asia and the Middle East respectively. Rabies developments in five different stages: incubation, prodrome, acute neurologic period, coma and death. Vaccination of people is important to prevent the spread of rabies. It is concluded that Asia is most effected region by rabies because many people die due to this virus in Asia as compare to others.