Rapamycin is an immunosuppressive drug used to prevent acute allograft rejection in solid
organ transplantation. It shows less nephrotoxicity than calcineurin inhibitors. We evaluated
the effect of rapamycin in rats undergoing 5/6 nephrectomy, a model of proteinuric and
progressive renal failure. Fourteen days after surgery rats were randomized either to receive
rapamycin or to remain untreated (control). Rats were humanely killed on day 91; serum
creatinine, creatinine clearance, and proteinuria were assessed. Renal sections were …