There is evidence that serotonin [5-hydroxytryptamine (5-HT)] is involved in the
physiological responses to hypercapnia. Serotonergic neurons represent the major cell type
(comprising 15–20% of the neurons) in raphe magnus nucleus (RMg), which is a medullary
raphe nucleus. In the present study, we tested the hypothesis 1) that RMg plays a role in the
ventilatory and thermal responses to hypercapnia, and 2) that RMg serotonergic neurons
are involved in these responses. To this end, we microinjected 1) ibotenic acid to promote …

Gargaglioni LH, Branco LG. Raphe magnus nucleus is involved in ventilatory but not
hypothermic response to CO2. J Appl Physiol 103: 1780–1788, 2007. First published
September 6, 2007; doi: 10.1152/japplphysiol. 00424.2007.—There is evidence that
serotonin [5-hydroxytryptamine (5-HT)] is involved in the physiological responses to
hypercapnia. Serotonergic neurons represent the major cell type (comprising 15–20% of the
neurons) in raphe magnus nucleus (RMg), which is a medullary raphe nucleus. In the …