Rapid decline of bacterial drug-resistance in an antibiotic-free environment through phenotypic reversion
Antibiotic resistance typically induces a fitness cost that shapes the fate of antibiotic-resistant
bacterial populations. However, the cost of resistance can be mitigated by compensatory
mutations elsewhere in the genome, and therefore the loss of resistance may proceed too
slowly to be of practical importance. We present our study on the efficacy and phenotypic
impact of compensatory evolution in Escherichia coli strains carrying multiple resistance
mutations. We have demonstrated that drug-resistance frequently declines within 480 …
bacterial populations. However, the cost of resistance can be mitigated by compensatory
mutations elsewhere in the genome, and therefore the loss of resistance may proceed too
slowly to be of practical importance. We present our study on the efficacy and phenotypic
impact of compensatory evolution in Escherichia coli strains carrying multiple resistance
mutations. We have demonstrated that drug-resistance frequently declines within 480 …
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