The term crescentic glomerulonephritis (GN) refers to a pathologic condition characterized
by extracapillary proliferation in> 50% of glomeruli. Clinically crescentic GN is characterized
by a nephritic syndrome rapidly progressing to end stage renal disease (ESRD). Three types
of crescentic GN have been identified. Type 1 includes cases of Goodpasture syndrome
characterized by linear deposits of antibodies along the glomerular basement membrane
(GBM) at immunofluorescence. Type 2 is a heterogeneous group of primary or secondary …

The renal biopsy demonstrated involvement of essentially all glomeruli by necrosis,
sclerosis, or both. Approximately 90% of glomeruli had cellular or fibrocellular crescents
(Fig. 1A). There was focal disruption of Bowman's capsule. Most glomeruli had prominent
adjacent periglomerular inflammation, including occasional multinucleated giant cells. A few
small foci of granulomatous inflammation were present but were centered on identifiable
glomeruli (Fig. 1C). Arteries and arterioles had moderate sclerosis as well as focal …