Rare Events in Population Genetics: Stochastic Tunneling in a Two-Locus<? format?> Model with Recombination
Physical review letters, 2011•APS
We study the evolution of a population in a two-locus genotype space, in which the negative
effects of two single mutations are overcompensated in a high-fitness double mutant. We
discuss how the interplay of finite population size N and sexual recombination at rate r
affects the escape times t esc to the double mutant. For small populations demographic
noise generates massive fluctuations in t esc. The mean escape time varies
nonmonotonically with r, and grows exponentially as ln t esc∼ N (rr*) 3/2 beyond a critical …
effects of two single mutations are overcompensated in a high-fitness double mutant. We
discuss how the interplay of finite population size N and sexual recombination at rate r
affects the escape times t esc to the double mutant. For small populations demographic
noise generates massive fluctuations in t esc. The mean escape time varies
nonmonotonically with r, and grows exponentially as ln t esc∼ N (rr*) 3/2 beyond a critical …
We study the evolution of a population in a two-locus genotype space, in which the negative effects of two single mutations are overcompensated in a high-fitness double mutant. We discuss how the interplay of finite population size and sexual recombination at rate affects the escape times to the double mutant. For small populations demographic noise generates massive fluctuations in . The mean escape time varies nonmonotonically with , and grows exponentially as lntesc∼N(r-r*)3/2 beyond a critical value .
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