[HTML][HTML] Re-assessing gallium-67 as a therapeutic radionuclide
MF bin Othman, NR Mitry, VJ Lewington… - Nuclear Medicine and …, 2017 - Elsevier
Introduction Despite its desirable half-life and low energy Auger electrons that travel further
than for other radionuclides, 67 Ga has been neglected as a therapeutic radionuclide. Here,
67 Ga is compared with Auger electron emitter 111 In as a potential therapeutic
radionuclide. Methods Plasmid pBR322 studies allowed direct comparison between 67 Ga
and 111 In (1 MBq) in causing DNA damage, including the effect of chelators (EDTA and
DTPA) and the effects of a free radical scavenger (DMSO). The cytotoxicity of internalized …
than for other radionuclides, 67 Ga has been neglected as a therapeutic radionuclide. Here,
67 Ga is compared with Auger electron emitter 111 In as a potential therapeutic
radionuclide. Methods Plasmid pBR322 studies allowed direct comparison between 67 Ga
and 111 In (1 MBq) in causing DNA damage, including the effect of chelators (EDTA and
DTPA) and the effects of a free radical scavenger (DMSO). The cytotoxicity of internalized …
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