Real-time analysis of large-scale neuronal imaging enables closed-loop investigation of neural dynamics

CF Shang, YF Wang, MT Zhao, QX Fan, S Zhao… - Nature …, 2024 - nature.com
CF Shang, YF Wang, MT Zhao, QX Fan, S Zhao, Y Qian, SJ Xu, Y Mu, J Hao, JL Du
Nature Neuroscience, 2024nature.com
Large-scale imaging of neuronal activities is crucial for understanding brain functions.
However, it is challenging to analyze large-scale imaging data in real time, preventing
closed-loop investigation of neural circuitry. Here we develop a real-time analysis system
with a field programmable gate array–graphics processing unit design for an up to 500-
megabyte-per-second image stream. Adapted to whole-brain imaging of awake larval
zebrafish, the system timely extracts activity from up to 100,000 neurons and enables closed …
Abstract
Large-scale imaging of neuronal activities is crucial for understanding brain functions. However, it is challenging to analyze large-scale imaging data in real time, preventing closed-loop investigation of neural circuitry. Here we develop a real-time analysis system with a field programmable gate array–graphics processing unit design for an up to 500-megabyte-per-second image stream. Adapted to whole-brain imaging of awake larval zebrafish, the system timely extracts activity from up to 100,000 neurons and enables closed-loop perturbations of neural dynamics.
nature.com
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