Real-time monitoring of the interactions of transforming growth factor-β (TGF-β) isoforms with latency-associated protein and the ectodomains of the TGF-β type II and …
G De Crescenzo, S Grothe, J Zwaagstra… - Journal of Biological …, 2001 - ASBMB
Mature transforming growth factor-β (TGF-β) is proteolytically derived from the C terminus of
a precursor protein. Latency-associated protein (LAP), the N-terminal remnant of the TGF-β
precursor, is able to bind and neutralize TGF-β. Mature TGF-β exerts its activity by binding
and complexing members of two subfamilies of receptors, the type I and II receptors. In
addition to these signaling receptors, TGF-β can also interact with an accessory receptor
termed the type III receptor. Using a surface plasmon resonance-based biosensor (BIAcore) …
a precursor protein. Latency-associated protein (LAP), the N-terminal remnant of the TGF-β
precursor, is able to bind and neutralize TGF-β. Mature TGF-β exerts its activity by binding
and complexing members of two subfamilies of receptors, the type I and II receptors. In
addition to these signaling receptors, TGF-β can also interact with an accessory receptor
termed the type III receptor. Using a surface plasmon resonance-based biosensor (BIAcore) …
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