a precursor protein. Latency-associated protein (LAP), the N-terminal remnant of the TGF-β
precursor, is able to bind and neutralize TGF-β. Mature TGF-β exerts its activity by binding
and complexing members of two subfamilies of receptors, the type I and II receptors. In
addition to these signaling receptors, TGF-β can also interact with an accessory receptor
termed the type III receptor. Using a surface plasmon resonance-based biosensor (BIAcore) …