Reciprocal Regulation of the Cardiac Epigenome by Chromatin Structural Proteins Hmgb and Ctcf
E Monte, M Rosa-Garrido, E Karbassi, H Chen… - Journal of biological …, 2016 - ASBMB
Transcriptome remodeling in heart disease occurs through the coordinated actions of
transcription factors, histone modifications, and other chromatin features at pathology-
associated genes. The extent to which genome-wide chromatin reorganization also
contributes to the resultant changes in gene expression remains unknown. We examined
the roles of two chromatin structural proteins, Ctcf (CCCTC-binding factor) and Hmgb2 (high
mobility group protein B2), in regulating pathologic transcription and chromatin remodeling …
transcription factors, histone modifications, and other chromatin features at pathology-
associated genes. The extent to which genome-wide chromatin reorganization also
contributes to the resultant changes in gene expression remains unknown. We examined
the roles of two chromatin structural proteins, Ctcf (CCCTC-binding factor) and Hmgb2 (high
mobility group protein B2), in regulating pathologic transcription and chromatin remodeling …
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