Recognition of β2-microglobulin-negative (β2m-) T-cell blasts by natural killer cells from normal but not from β2m-mice: nonresponsiveness controlled by β2m-bone …
P Hoglund, C Ohlen, E Carbone, L Franksson… - Proceedings of the …, 1991 - JSTOR
The role of major histocompatibility complex (MHC) class I expression in control of the
sensitivity of normal cells to natural killer (NK) cells was studied by the use of mutant mice
made deficient for expression of β2-microglobulin (β2m) through homologous recombination
in embryonal stem cells. T-cell blasts from β2m-deficient (β2m-/-) mice were killed by NK
cells from normal mice in vitro, while β2m+/-blasts were resistant. The β2m defect also
affected the NK effector cell repertoire: NK cells from β2m-/-mice failed to kill β2m-/-blasts …
sensitivity of normal cells to natural killer (NK) cells was studied by the use of mutant mice
made deficient for expression of β2-microglobulin (β2m) through homologous recombination
in embryonal stem cells. T-cell blasts from β2m-deficient (β2m-/-) mice were killed by NK
cells from normal mice in vitro, while β2m+/-blasts were resistant. The β2m defect also
affected the NK effector cell repertoire: NK cells from β2m-/-mice failed to kill β2m-/-blasts …
Recognition of beta 2-microglobulin-negative (beta 2m-) T-cell blasts by natural killer cells from normal but not from beta 2m-mice: nonresponsiveness controlled by …
The role of major histocompatibility complex (MHC) class I expression in control of the
sensitivity of normal cells to natural killer (NK) cells was studied by the use of mutant mice
made deficient for expression of beta 2-microglobulin (beta 2m) through homologous
recombination in embryonal stem cells. T-cell blasts from beta 2m-deficient (beta 2m-/-) mice
were killed by NK cells from normal mice in vitro, while beta 2m+/-blasts were resistant. The
beta 2m defect also affected the NK effector cell repertoire: NK cells from beta 2m-/-mice …
sensitivity of normal cells to natural killer (NK) cells was studied by the use of mutant mice
made deficient for expression of beta 2-microglobulin (beta 2m) through homologous
recombination in embryonal stem cells. T-cell blasts from beta 2m-deficient (beta 2m-/-) mice
were killed by NK cells from normal mice in vitro, while beta 2m+/-blasts were resistant. The
beta 2m defect also affected the NK effector cell repertoire: NK cells from beta 2m-/-mice …
以上显示的是最相近的搜索结果。 查看全部搜索结果