Recombinant Plasmodium vivax circumsporozoite surface protein allelic variants: antibody recognition by individuals from three communities in the Brazilian Amazon
IF Soares, C López-Camacho… - Scientific reports, 2020 - nature.com
Circumsporozoite protein (CSP) variants of P. vivax, besides having variations in the protein
repetitive portion, can differ from each other in aspects such as geographical distribution,
intensity of transmission, vectorial competence and immune response. Such aspects must
be considered to P. vivax vaccine development. Therefore, we evaluated the
immunogenicity of novel recombinant proteins corresponding to each of the three P. vivax
allelic variants (VK210, VK247 and P. vivax-like) and of the C-terminal region (shared by all …
repetitive portion, can differ from each other in aspects such as geographical distribution,
intensity of transmission, vectorial competence and immune response. Such aspects must
be considered to P. vivax vaccine development. Therefore, we evaluated the
immunogenicity of novel recombinant proteins corresponding to each of the three P. vivax
allelic variants (VK210, VK247 and P. vivax-like) and of the C-terminal region (shared by all …
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