Transmission of malaria parasites from humans to Anopheles mosquitoes can be inhibited
by specific antibodies elicited during malaria infection, which target surface Plasmodium
gametocyte/gamete proteins. Some of these proteins may have potential for vaccine
development. Pvs 48/45 is a P. vivax gametocyte surface antigen orthologous to Pfs 48/45,
which may play a role during parasite fertilization and thus has potential for transmission
blocking (TB) activity. Here we describe the expression of a recombinant Pvs 48/45 protein …

The article [1] states,“The protocol was approved by the Committee for Animal Ethics of
MVDC.” A governmental official informed PLOS that the animal ethics committees of Malaria
Vaccine and Drug Development Center (MVDC) and Fundación Centro de Primates
(FUCEP) did not comply with Colombian regulations regarding the use of animals in
research, and as such were not authorized to provide ethics approval for animal research.
The corresponding and last authors stated that the governmental agency whom PLOS …