Reconciling contradictory findings: Glucose transporter 1 (GLUT1) functions as an oligomer of allosteric, alternating access transporters
KP Lloyd, OA Ojelabi, JK De Zutter… - Journal of Biological …, 2017 - ASBMB
Recent structural studies suggest that GLUT1 (glucose transporter 1)-mediated sugar
transport is mediated by an alternating access transporter that successively presents
exofacial (e2) and endofacial (e1) substrate-binding sites. Transport studies, however,
indicate multiple, interacting (allosteric), and co-existent, exo-and endofacial GLUT1 ligand-
binding sites. The present study asks whether these contradictory conclusions result from
systematic analytical error or reveal a more fundamental relationship between transporter …
transport is mediated by an alternating access transporter that successively presents
exofacial (e2) and endofacial (e1) substrate-binding sites. Transport studies, however,
indicate multiple, interacting (allosteric), and co-existent, exo-and endofacial GLUT1 ligand-
binding sites. The present study asks whether these contradictory conclusions result from
systematic analytical error or reveal a more fundamental relationship between transporter …
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