Recruitment of resting vesicles into recycling pools supports NMDA receptor‐dependent synaptic potentiation in cultured hippocampal neurons
The Journal of physiology, 2012•Wiley Online Library
Key points• Presynaptic terminals in hippocampal neurons are characterized by two
functionally defined vesicle populations: a recycling pool, which supports activity‐evoked
neurotransmission, and a resting pool.• Between individual synapses, the relative
proportions of these two pools are highly variable, suggesting that this parameter might be
specifically regulated to support changes in synaptic efficacy.• Using fluorescence imaging
and correlative ultrastructural approaches we show here that a form of synaptic potentiation …
functionally defined vesicle populations: a recycling pool, which supports activity‐evoked
neurotransmission, and a resting pool.• Between individual synapses, the relative
proportions of these two pools are highly variable, suggesting that this parameter might be
specifically regulated to support changes in synaptic efficacy.• Using fluorescence imaging
and correlative ultrastructural approaches we show here that a form of synaptic potentiation …
Key points
- • Presynaptic terminals in hippocampal neurons are characterized by two functionally defined vesicle populations: a recycling pool, which supports activity‐evoked neurotransmission, and a resting pool.
- • Between individual synapses, the relative proportions of these two pools are highly variable, suggesting that this parameter might be specifically regulated to support changes in synaptic efficacy.
- • Using fluorescence imaging and correlative ultrastructural approaches we show here that a form of synaptic potentiation dependent on N‐methyl‐d‐aspartic acid (NMDA) receptor activity can lead to a rapid and sustained expansion of the recycling fraction at the expense of the resting pool.
- • This recruitment of vesicles depends on nitric oxide signalling and calcineurin activity, and is accompanied by an increase in synaptic release probability.
- • We suggest that vesicle exchange between these pools provides a rapid mechanism to support adjustments in synaptic strength associated with a form of Hebbian plasticity.
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