Reduced immune response to Borrelia burgdorferi in the absence of γδ T cells

C Shi, B Sahay, JQ Russell, KA Fortner… - Infection and …, 2011 - Am Soc Microbiol
C Shi, B Sahay, JQ Russell, KA Fortner, N Hardin, TJ Sellati, RC Budd
Infection and immunity, 2011Am Soc Microbiol
Little is known regarding the function of γδ T cells, although they accumulate at sites of
inflammation in infections and autoimmune disorders. We previously observed that γδ T
cells in vitro are activated by Borrelia burgdorferi in a TLR2-dependent manner. We now
observe that the activated γδ T cells can in turn stimulate dendritic cells in vitro to produce
cytokines and chemokines that are important for the adaptive immune response. This
suggested that in vivo γδ T cells may assist in activating the adaptive immune response. We …
Abstract
Little is known regarding the function of γδ T cells, although they accumulate at sites of inflammation in infections and autoimmune disorders. We previously observed that γδ T cells in vitro are activated by Borrelia burgdorferi in a TLR2-dependent manner. We now observe that the activated γδ T cells can in turn stimulate dendritic cells in vitro to produce cytokines and chemokines that are important for the adaptive immune response. This suggested that in vivo γδ T cells may assist in activating the adaptive immune response. We examined this possibility in vivo and observed that γδ T cells are activated and expand in number during Borrelia infection, and this was reduced in the absence of TLR2. Furthermore, in the absence of γδ T cells, there was a significantly blunted response of adaptive immunity, as reflected in reduced expansion of T and B cells and reduced serum levels of anti-Borrelia antibodies, cytokines, and chemokines. This paralleled a greater Borrelia burden in γδ-deficient mice as well as more cardiac inflammation. These findings are consistent with a model of γδ T cells functioning to promote the adaptive immune response during infection.
American Society for Microbiology
以上显示的是最相近的搜索结果。 查看全部搜索结果