… 2‘-O-modified regions and a 2‘-deoxyoligonucleotide phosphorothioate region that allows
RNase H digestion of mRNA. Among the various 2‘-O-modified … the subsequent regioselective …

… synthesis of new 2′-O-modified ribonucleosides, which involved highly selective oxa-Michael
additions for purine nucleotides … 24 underwent smooth regioselective Michael additions …

… O-modified nucleosides are known to act as chain terminator exerting antiviral activity. The
synthesis … simple and regioselective protocol offers a wide scope to synthesize numerous 3′-…

… Omodified nucleosides are known to act as chain terminator exerting antiviral activity. The
synthesis … simple and regioselective protocol offers a wide scope to synthesize numerous 3’-O-…

… A number of 2′-O-modified antisense oligonucleotides have … , we observed a highly
regioselective alkylation of the 2′- vs … for multigram scale synthesis of 2′-O-NMA nucleosides …

… of TOM or TBDMS (TIPS favorably gave higher 20-regioselectivity in the silylation step).
Construction of the modified nucleoside phosphoramidite 73 followed a 12-step synthetic route …

… • Protecting group strategy for the synthesis of the 2-O-modified … during conditions used in
oligonucleotide synthesis. … available nucleoside phosphoramidites we decided to synthesize …

… At the level of nucleosides, the synthesis of 2′-O-(2,4,6-trinitrophenyl)… a 2′,3′-cyclic spiro
ring. (8) Thus far, little has been reported about the general and regioselective synthesis of 2…

… base alkylation, low regioselectivity, dependence of hazardous … the synthesis of 2′-O-modified
nucleosides, we carried out 2′-O-benzylation of three types of 3′,5′-O-protected 2′-…

… analysis for the synthesis of bicyclic N,O nucleoside analogues … the synthesis of bicyclic
N,O-modified nucleosides and has … (iv) These 32CA reactions are ortho regioselective and exo …