Regulation of Ku-DNA association by Yku70 C-terminal tail and SUMO modification
LE Hang, CR Lopez, X Liu, JM Williams, I Chung… - Journal of Biological …, 2014 - ASBMB
The Ku70-Ku80 ring complex encloses DNA ends to facilitate telomere maintenance and
DNA break repair. Many studies focus on the ring-forming regions of subunits Ku70 and
Ku80. Less is known about the Ku70 C-terminal tail, which lies outside the ring. Our results
suggest that this region is responsible for dynamic sumoylation of Yku70 upon DNA
association in budding yeast. Mutating a cluster of five lysines in this region largely
eliminates Yku70 sumoylation. Chromatin immunoprecipitation analyses show that yku70 …
DNA break repair. Many studies focus on the ring-forming regions of subunits Ku70 and
Ku80. Less is known about the Ku70 C-terminal tail, which lies outside the ring. Our results
suggest that this region is responsible for dynamic sumoylation of Yku70 upon DNA
association in budding yeast. Mutating a cluster of five lysines in this region largely
eliminates Yku70 sumoylation. Chromatin immunoprecipitation analyses show that yku70 …
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