Regulation of the early expression of MAFbx/atrogin-1 and MuRF1 through membrane-initiated cortisol action in the skeletal muscle of rainbow trout
Glucocorticoids are key stress-related hormones in vertebrates, with cortisol being the main
glucocorticoid in teleosts. Glucocorticoids exert their effects through two mechanisms of
action: genomic/classic and membrane initiated. In mammals, cortisol-mediated stress has
been found to be associated with increased expression of critical atrophy-related genes
(atrogenes), such as MAFbx/atrogin-1 and murf1/trim63. However, the direct impact of
cortisol on the early regulation of atrogene expression in teleost skeletal muscle and the …
glucocorticoid in teleosts. Glucocorticoids exert their effects through two mechanisms of
action: genomic/classic and membrane initiated. In mammals, cortisol-mediated stress has
been found to be associated with increased expression of critical atrophy-related genes
(atrogenes), such as MAFbx/atrogin-1 and murf1/trim63. However, the direct impact of
cortisol on the early regulation of atrogene expression in teleost skeletal muscle and the …
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