Regulatory T cell lineage specification by the forkhead transcription factor foxp3
JD Fontenot, JP Rasmussen, LM Williams, JL Dooley… - Immunity, 2005 - cell.com
Regulatory T cell-mediated dominant tolerance has been demonstrated to play an important
role in the prevention of autoimmunity. Here, we present data arguing that the forkhead
transcription factor Foxp3 acts as the regulatory T cell lineage specification factor and
mediator of the genetic mechanism of dominant tolerance. We show that expression of
Foxp3 is highly restricted to the subset αβ of T cells and, irrespective of CD25 expression,
correlates with suppressor activity. Induction of Foxp3 expression in nonregulatory T cells …
role in the prevention of autoimmunity. Here, we present data arguing that the forkhead
transcription factor Foxp3 acts as the regulatory T cell lineage specification factor and
mediator of the genetic mechanism of dominant tolerance. We show that expression of
Foxp3 is highly restricted to the subset αβ of T cells and, irrespective of CD25 expression,
correlates with suppressor activity. Induction of Foxp3 expression in nonregulatory T cells …
[引用][C] Regulatory T cell lineage specification by the forkhead transcription factor foxp3
F Jd - Immunity, 2005 - cir.nii.ac.jp
Regulatory T cell lineage specification by the forkhead transcription factor foxp3 | CiNii
Research … Regulatory T cell lineage specification by the forkhead transcription factor foxp3 …
Research … Regulatory T cell lineage specification by the forkhead transcription factor foxp3 …
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