Relationship between baseline hepatic status and outcome, and effect of sorafenib on liver function: SHARP trial subanalyses
BACKGROUND & AIMS: Hepatic markers are utilized in many classification systems of
patients with hepatocellular carcinoma and, by measuring organ damage and tumor stage,
can influence treatment. Moreover, elevated serum concentrations of aminotransferases and
alpha-fetoprotein are indicators of poor prognosis in patients with hepatocellular carcinoma.
We examined the effects of sorafenib on hepatic markers by performing exploratory subset
analyses of the Sorafenib HCC Assessment Randomized Protocol (SHARP) trial in patients …
patients with hepatocellular carcinoma and, by measuring organ damage and tumor stage,
can influence treatment. Moreover, elevated serum concentrations of aminotransferases and
alpha-fetoprotein are indicators of poor prognosis in patients with hepatocellular carcinoma.
We examined the effects of sorafenib on hepatic markers by performing exploratory subset
analyses of the Sorafenib HCC Assessment Randomized Protocol (SHARP) trial in patients …
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