Relationship between pain and medial knee joint loading in mild radiographic knee osteoarthritis
Objective The relationship between knee pain and radiographic evidence of knee
osteoarthritis (OA) is notoriously imperfect. In particular, conditions that distinguish
individuals with symptoms from those with comparable radiographic involvement who
remain asymptomatic are unclear. We investigated dynamic loading across the knee in
individuals with mild radiographic OA who were distinguished by the presence or absence
of knee pain. Methods Subjects were recruited into 3 groups: symptomatic with a …
osteoarthritis (OA) is notoriously imperfect. In particular, conditions that distinguish
individuals with symptoms from those with comparable radiographic involvement who
remain asymptomatic are unclear. We investigated dynamic loading across the knee in
individuals with mild radiographic OA who were distinguished by the presence or absence
of knee pain. Methods Subjects were recruited into 3 groups: symptomatic with a …
Objective
The relationship between knee pain and radiographic evidence of knee osteoarthritis (OA) is notoriously imperfect. In particular, conditions that distinguish individuals with symptoms from those with comparable radiographic involvement who remain asymptomatic are unclear. We investigated dynamic loading across the knee in individuals with mild radiographic OA who were distinguished by the presence or absence of knee pain.
Methods
Subjects were recruited into 3 groups: symptomatic with a Kellgren/Lawrence (K/L) grade of 2 (n = 52), asymptomatic with a K/L grade of 2 (n = 19), and asymptomatic with a K/L grade of 0 or 1 (n = 37), the latter representing a normal comparator group. Dynamic knee loading was assessed with gait analysis, and both the peak external knee adduction moment and the knee adduction angular impulse were determined.
Results
Peak knee adduction moment and knee adduction angular impulse were 19% and 30% higher, respectively, in symptomatic K/L grade 2 individuals than in asymptomatic individuals with the same radiographic grade (P < 0.05). Conversely, the asymptomatic K/L grade 2 group did not differ from the K/L grade 0–1 normal comparator group (P = 1.00).
Conclusion
Among individuals with mild radiographic knee OA (K/L grade 2), those who are symptomatic have significantly higher medial compartment loads than those who are asymptomatic, whereas those who are asymptomatic do not differ from normal controls (asymptomatic K/L grade 0 or 1). These findings suggest a biomechanical component to the distinction between asymptomatic and symptomatic radiographic OA, which may be pathophysiologically important.
Wiley Online Library以上显示的是最相近的搜索结果。 查看全部搜索结果