The aim of this study was to recognize factors associated with cancer of oral cavity considering socio-demographic characteristics. The cases were 350 with squamous-cell carcinoma of oral cavity diagnosed between 2005 and 2006 in Morbai, Narandia, Budharani Cancer Institute, Pune, India. Similar number of controls match for age and sex selected from the background population. Cases and controls were interviewed for tobacco related habits and general characteristics; age, gender, education and possible socio-demographic factors. Chi-square test in uni-variate analysis and estimate for risk showed that education, occupation and monthly household income were significantly different between cases and controls (P < 0.001). Irrespective to gender, relative risk, here odds ratio, (OR) of low level of education (OR = 5.3, CI 3.7–7.6), working in field as a farmer (OR = 2.5, CI 1.7–3.7), and monthly household income less than 5000 Indian Rupees currency (OR = 1.7, CI 1.2–2.3) were significant risk factors for oral cancer. While, there was no significant relationship between religious and or marital status either in males or females.