Release of c-FLIP brake selectively sensitizes human cancer cells to TLR3-mediated apoptosis
Abstract Toll-like receptor 3 (TLR3) mediates innate immune responses by sensing viral
dsRNA, but also induces apoptosis selectively in cancer cells. Our analysis by
immunohistochemistry revealed that TLR3 is frequently overexpressed in 130 non-small cell
lung cancer (NSCLC) patients' samples compared with normal bronchial epithelium (P<
0.0001, Mann–Whitney test), supporting the therapeutic potential of TLR3 ligand for this type
of cancer. However, a proportion of TLR3-expressing cancer cell lines, including NSCLC …
dsRNA, but also induces apoptosis selectively in cancer cells. Our analysis by
immunohistochemistry revealed that TLR3 is frequently overexpressed in 130 non-small cell
lung cancer (NSCLC) patients' samples compared with normal bronchial epithelium (P<
0.0001, Mann–Whitney test), supporting the therapeutic potential of TLR3 ligand for this type
of cancer. However, a proportion of TLR3-expressing cancer cell lines, including NSCLC …
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