MnCuO_x/TiO₂ supported catalyst was synthesized by the incipient wetness impregnation method. The catalyst was then tested for the oxidation of chlorobenzene (CB) used as a Cl-VOC model. The results showed that MnCuO_x/TiO₂ is very active for CB oxidation since a total conversion (exclusively into H₂O, CO₂ and Cl₂) was reached at 350°C without formation of any other harmful organic compounds and no catalyst deactivation was observed. This performance was attributed to the formation Mn_1.6Cu_1.4O₄ spinel phase. However, at lower temperatures, some deactivation occurred before a steady-state is reached. At 300°C, the CB conversion decreased and stabilised at 75% after 5h and a small amount of HCl and traces of CO were detected. The reason why HCl was not detected at temperatures higher than 350°C was explained by Deacon reaction. SEM/EDS analysis revealed the presence of chlorine uniformly dispersed on the catalyst surface. The formation of chlorinated compound (MnCuO_x−aCl_2a/TiO₂), which is presumed to be responsible of the catalyst partial deactivation, was confirmed by other analysis experiments (TG/DTA, TPR). The catalyst regeneration under air at 350°C allowed the system to recover the initial activity in spite of the fact that the chlorine was not completely removed from the catalyst.