… repair pathway. This article will review the classes of DNA damage that are amenable …
repair in mtDNA, the current understanding of the enzymatic machinery available for DNA repair …

… The cloning of putative vertebrate mtDNA repair genes shouldconfirm the mitochondrial
localization of these enzymes. An example of thisstrategy is the cloning of two yeast homologs of …

… expanded our knowledge of mtDNA repair to include long-patch base excision repair …
In this review, we will focus on recent progress in elucidating mtDNA repair pathways in …

… of replication, repair and mutagenesis of the vertebrate mitochondrial genome revealed …
In this review, we will discuss the basic mechanisms of mtDNA replication, repair, and …

… The lack of both replicative and post-replicative repair of vertebrate mtDNA may thus be
due to the lack of an a-polymerase in the mitochondria. Three forms of DNA polymerase have …

… stress and aging in different vertebrate species and in caloricrestricted … repair of mtDNA in
relation to nDNA. However, while mtDNA lacks some forms of DNA repair, its capacity to repair …

… breaks/13.5 kb fragment) which may complicate accurate assessment of the repair, this study
suggests that decreased mtDNA repair contributes to the observed clinical features in DS. …

… DNA (mtDNA) is wholly dependent on the nucleus for its replication and maintenance factors,
at least in vertebrates. … mtDNA molecules of higher vertebrates frequently bear a short triple-…

… mtDNA replication and repair machinery and that most animal genomes have the necessary
enzymes for mtDNA … in a taxonomically wide variety of invertebrate and vertebrate species [ …

… of mtDNA, a situation termed heteroplasmy. Understanding mtDNA repair mechanisms
could … In particular, mismatch repair activity could potentially be used to repair pathogenic …