Reproducible diagnosis of chronic lymphocytic leukemia by flow cytometry: An European Research Initiative on CLL (ERIC) & European Society for Clinical Cell …
AC Rawstron, KA Kreuzer, A Soosapilla… - Cytometry Part B …, 2018 - Wiley Online Library
The diagnostic criteria for CLL rely on morphology and immunophenotype. Current
approaches have limitations affecting reproducibility and there is no consensus on the role
of new markers. The aim of this project was to identify reproducible criteria and consensus
on markers recommended for the diagnosis of CLL. ERIC/ESCCA members classified 14 of
35 potential markers as “required” or “recommended” for CLL diagnosis, consensus being
defined as> 75% and> 50% agreement, respectively. An approach to validate “required” …
approaches have limitations affecting reproducibility and there is no consensus on the role
of new markers. The aim of this project was to identify reproducible criteria and consensus
on markers recommended for the diagnosis of CLL. ERIC/ESCCA members classified 14 of
35 potential markers as “required” or “recommended” for CLL diagnosis, consensus being
defined as> 75% and> 50% agreement, respectively. An approach to validate “required” …
Reproducible Diagnosis of Chronic Lymphocytic Leukemia (CLL) By Flow Cytometry: An European Research Initiative on CLL (ERIC) & European Society for Clinical …
AC Rawstron, KA Kreuzer, A Soosapilla, M Spacek… - 2015 - ashpublications.org
Abstract BACKGROUND: The WHO and iwCLL diagnostic criteria for CLL rely on
morphology and immunophenotype based on the co-expression of CD19/CD5/CD23 on B-
cells with weak CD20 and monoclonal sIg expression. These diagnostic criteria are likely to
persist in the near future because there is no specific diagnostic molecular abnormality for
CLL. The current criteria have some limitations affecting reproducibility, particularly flexibility
in marker expression with many centres using a scoring system that permits absence of CD5 …
morphology and immunophenotype based on the co-expression of CD19/CD5/CD23 on B-
cells with weak CD20 and monoclonal sIg expression. These diagnostic criteria are likely to
persist in the near future because there is no specific diagnostic molecular abnormality for
CLL. The current criteria have some limitations affecting reproducibility, particularly flexibility
in marker expression with many centres using a scoring system that permits absence of CD5 …
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