Generation of inhibitory antibodies upon repeated FVIII infusion represents a major
complication in hemophilia care. Professional antigen presenting cells (APCs) are crucial for
orchestration of humoral immune responses. APCs are capable of internalizing soluble as
well as particulate antigens through various mechanisms resulting in loading of antigen-
derived peptides on MHC class I or II for presentation to T cells. This review highlights how
FVIII is recognized and processed by APCs. The significance and contribution of candidate …