Alzheimer's disease neuropathologic change (ADNC) is defined by progressive
accumulation of β-amyloid plaques and hyperphosphorylated tau (pTau) neurofibrillary
tangles across diverse regions of brain. Non-demented individuals who reach advanced
age without significant ADNC are considered to be resistant to AD, while those burdened
with ADNC are considered to be resilient. Understanding mechanisms underlying ADNC
resistance and resilience may provide important clues to treating and/or preventing AD …

Dementia is a significant public health crisis; the most common underlying cause of age-
related cognitive decline and dementia is Alzheimer's disease neuropathologic change
(ADNC). As such, there is an urgent need to identify novel therapeutic targets for the
treatment and prevention of the underlying pathologic processes that contribute to the
development of AD dementia. Although age is the top risk factor for dementia in general and
AD specifically, these are not inevitable consequences of advanced age. Some individuals …