[HTML][HTML] Resolvin D1 treatment on goblet cell mucin and immune responses in the chronic allergic eye disease (AED) model
Severe, chronic eye allergy is an understudied, vision-threatening condition. Treatments
remain limited. We used a mouse model of severe allergic eye disease (AED) to determine
whether topical application of the pro-resolution mediator Resolvin D1 (RvD1) terminates
the response. AED was induced by injection of ovalbumin (OVA) followed by topical
challenge of OVA daily. RvD1 was applied topically prior to OVA. Clinical symptoms were
scored. Eye washes were assayed for MUC5AC. After 7 days, eyes were removed and the …
remain limited. We used a mouse model of severe allergic eye disease (AED) to determine
whether topical application of the pro-resolution mediator Resolvin D1 (RvD1) terminates
the response. AED was induced by injection of ovalbumin (OVA) followed by topical
challenge of OVA daily. RvD1 was applied topically prior to OVA. Clinical symptoms were
scored. Eye washes were assayed for MUC5AC. After 7 days, eyes were removed and the …
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