Restoring leptin signaling reduces hyperlipidemia and improves vascular stiffness induced by chronic intermittent hypoxia
Chronic intermittent hypoxia (IH) during sleep can result from obstructive sleep apnea
(OSA), a disorder that is particularly prevalent in obesity. OSA is associated with high levels
of circulating leptin, cardiovascular dysfunction, and dyslipidemia. Relationships between
leptin and cardiovascular function in OSA and chronic IH are poorly understood. We
exposed lean wild-type (WT) and obese leptin-deficient ob/ob mice to IH for 4 wk, with and
without leptin infusion, and measured cardiovascular indices including aortic vascular …
(OSA), a disorder that is particularly prevalent in obesity. OSA is associated with high levels
of circulating leptin, cardiovascular dysfunction, and dyslipidemia. Relationships between
leptin and cardiovascular function in OSA and chronic IH are poorly understood. We
exposed lean wild-type (WT) and obese leptin-deficient ob/ob mice to IH for 4 wk, with and
without leptin infusion, and measured cardiovascular indices including aortic vascular …
Restoring Leptin Signaling Reduces Hyperlipidemia and Improves Vascular Stiffness Induced by Chronic Intermittent Hypoxia 2
KL Ellis, A Camera, C Reinke, V Savransky… - 2011 - journals.physiology.org
Chronic intermittent hypoxia (IH) during sleep can result from obstructive sleep apnea 48
(OSA), a disorder that is particularly prevalent in obesity. OSA is associated with high levels
of 49 circulating leptin, cardiovascular dysfunction, and dyslipidemia. Relationships between
leptin 50 and cardiovascular function in OSA and chronic IH are poorly understood. We
exposed lean 51 wild-type (WT) and obese leptin-deficient ob/ob mice to IH for 4 weeks, with
and without leptin 52 infusion, and measured cardiovascular indices including aortic …
(OSA), a disorder that is particularly prevalent in obesity. OSA is associated with high levels
of 49 circulating leptin, cardiovascular dysfunction, and dyslipidemia. Relationships between
leptin 50 and cardiovascular function in OSA and chronic IH are poorly understood. We
exposed lean 51 wild-type (WT) and obese leptin-deficient ob/ob mice to IH for 4 weeks, with
and without leptin 52 infusion, and measured cardiovascular indices including aortic …