Resveratrol suppresses the inducible expression of CYP3A4 through the pregnane X receptor
R Deng, C Xu, X Chen, P Chen, Y Wang… - Journal of …, 2014 - jstage.jst.go.jp
The pregnane X receptor (PXR, NR1I2), a member of the nuclear receptor superfamily, is
activated by a number of clinically prescribed drugs and herbal extracts. The inducible
expression of several important cytochrome P450 (CYP450) enzymes has been shown to be
regulated by the activation of PXR in the liver. In the current study, reporter gene–transfected
cells were used to identify potential antagonists of PXR. Here, we showed that resveratrol
(RES), a natural polyphenolic compound could significantly suppress the rifampicin-induced …
activated by a number of clinically prescribed drugs and herbal extracts. The inducible
expression of several important cytochrome P450 (CYP450) enzymes has been shown to be
regulated by the activation of PXR in the liver. In the current study, reporter gene–transfected
cells were used to identify potential antagonists of PXR. Here, we showed that resveratrol
(RES), a natural polyphenolic compound could significantly suppress the rifampicin-induced …
Resveratrol suppresses the inducible expression of CYP3A4 through the pregnane X receptor.
DRR Deng RongRong, XCS Xu ChenShu… - 2014 - cabidigitallibrary.org
The pregnane X receptor (PXR, NR1I2), a member of the nuclear receptor superfamily, is
activated by a number of clinically prescribed drugs and herbal extracts. The inducible
expression of several important cytochrome P450 (CYP450) enzymes has been shown to be
regulated by the activation of PXR in the liver. In the current study, reporter gene-transfected
cells were used to identify potential antagonists of PXR. Here, we showed that resveratrol
(RES), a natural polyphenolic compound could significantly suppress the rifampicin-induced …
activated by a number of clinically prescribed drugs and herbal extracts. The inducible
expression of several important cytochrome P450 (CYP450) enzymes has been shown to be
regulated by the activation of PXR in the liver. In the current study, reporter gene-transfected
cells were used to identify potential antagonists of PXR. Here, we showed that resveratrol
(RES), a natural polyphenolic compound could significantly suppress the rifampicin-induced …
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