Reversal of the pathophysiological responses to gram-negative sepsis by megadose vitamin C
YR Lankadeva, RM Peiris, N Okazaki… - Critical care …, 2021 - journals.lww.com
Objectives: Oxidative stress appears to initiate organ failure in sepsis, justifying treatment
with antioxidants such as vitamin C at megadoses. We have therefore investigated the safety
and efficacy of megadose sodium ascorbate in sepsis. Design: Interventional study. Setting:
Research Institute. Subjects: Adult Merino ewes. Interventions: Sheep were instrumented
with pulmonary and renal artery flow-probes, and laser-Doppler and oxygen-sensing probes
in the kidney. Conscious sheep received an infusion of live Escherichia coli for 31 hours. At …
with antioxidants such as vitamin C at megadoses. We have therefore investigated the safety
and efficacy of megadose sodium ascorbate in sepsis. Design: Interventional study. Setting:
Research Institute. Subjects: Adult Merino ewes. Interventions: Sheep were instrumented
with pulmonary and renal artery flow-probes, and laser-Doppler and oxygen-sensing probes
in the kidney. Conscious sheep received an infusion of live Escherichia coli for 31 hours. At …
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