Revisiting the role of glycosylation in the structure of human IgG Fc
Binding of the Fc domain of Immunoglobulin G (IgG) to Fcγ receptors on leukocytes can
initiate a series of signaling events resulting in antibody-dependent cell-mediated
cytotoxicity (ADCC) and other important immune responses. Fc domains lacking
glycosylation at N297 have greatly diminished Fcγ receptor binding and lack the ability to
initiate a robust ADCC response. Earlier structural studies of Fc domains with either full
length or truncated N297 glycans led to the proposal that these glycans can stabilize an …
initiate a series of signaling events resulting in antibody-dependent cell-mediated
cytotoxicity (ADCC) and other important immune responses. Fc domains lacking
glycosylation at N297 have greatly diminished Fcγ receptor binding and lack the ability to
initiate a robust ADCC response. Earlier structural studies of Fc domains with either full
length or truncated N297 glycans led to the proposal that these glycans can stabilize an …
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