Mitochondrial protein (MP) assemblies undergo alterations during neurogenesis, a complex
process vital in brain homeostasis and disease. Yet which MP assemblies remodel during
differentiation remains unclear. Here, using mass spectrometry-based co-fractionation
profiles and phosphoproteomics, we generated mitochondrial interaction maps of human
pluripotent embryonal carcinoma stem cells and differentiated neuronal-like cells, which
presented as two discrete cell populations by single-cell RNA sequencing. The resulting …