Etiology and pathogenesis. The etiopathogenesis of the syndrome has not been studied to the end. The classic Reye syndrome is developed as a result of the intake of salicylic acid products in the capacity of antipyretics by children with acute respiratory viral infections and other viral infections (mostly influenza, chickenpox, herpes, enterovirus infection, parainfluenza). It should be emphasized that it is not about overdose of salicylates, but about their reception within the limits of recommended age doses. There are many published case-control investigations that confirm the strong link between aspirin and Reye syndrome. The authors came to the conclusion that any amount of aspirin is dangerous for a child with a viral infection, regardless of its dose [22, 24, 37].